Adult:Adult: Initially, 150 mg daily increased by 50-mg increments every 3-4 days up to 300-400 mg daily if necessary. Daily dosage may be given in divided doses or as a single dose at night. Max: 600 mg daily in divided doses in severely depressed patients. Elderly: Initially, 100 mg daily up to 300 mg daily. Daily dosage may be given in divided doses or as a single dose at night.
Oral
TREATMENT OF ANXIETY
Adult:
Initially, 75 mg daily increased to 300 mg daily if necessary. Daily dosage may be given in divided doses or as a single dose at night.
Administration
Should be taken with food. (Take shortly after a meal or a light snack.)
Precautions
Cardiovascular disorders, epilepsy, severe hepatic or renal insufficiency. Lactation. Monitor closely during initial therapy for signs of suicide. Discontinue if signs of hepatic dysfunction, blood dyscrasias or prolonged erection. Withdraw gradually. May impair ability to drive or operate machinery.
Potentially Life-threatening
Adverse Drug Reactions
Dangerous combination with MAOIs. Trazodone should not be given within 2 wk of discontinuing MAOIs and MAOIs should not be started within 1 wk of discontinuing trazodone.
May diminish action of some antihypertensives (e.g. clonidine). Increased trazodone concentrations with potent CYP3A4 inhibitors such as azole antifungals, HIV-protease inhibitors and macrolides. Reduced trazodone concentrations with CYP3A4 inducers such as carbamazepine. Increased risk of excessive hypotension and hepatotoxicity with phenothiazines. Decreased anticoagulant effect of warfarin. Increased digoxin or phenytoin levels with trazodone. Increased risk of neurotoxicity, serotonin syndrome with lithium. Sedative effect enhanced by alcohol and other CNS depressants (sedatives, hypnotics, antihistamines, opioid analgesics).
